Thanos must go through a lot of chairs...

In case you thought I was joking about Thanos and his vendetta against Deadpool, here's the proof, from Deadpool #64, "Funeral for a Freak, part 4 of 4, Deadpoolalooza!" This was the last issue from writers Frank Tieri and Buddy Scalera, penciler Jim Calafiore, and inkers Wong and McKenna; next month Gail Simone and Udon would tear that sucker up. So, #64 isn't the worst Deadpool issue ever, and they do pick the place up when they're done.

Let's look at one more page, from #60, "Deadpool, Agent of Weapon X, part 4: Flatline" Written by Frank Tieri, pencils by Georges Jeanty, inks by Holdredge and Wong. The Weapon X program lures in Deadpool by juicing up his healing factor to insane levels, but after Sabretooth (on orders of the Director) kills Wade's old flame Vanessa, all bets are off: Wade kills Kane, fights through Wild Child and Sauron, before getting to the big boss:

What is with Sabretooth's fingerless opera gloves there? The fight goes south pretty quickly for Deadpool, as Weapon X deactivates his healing factor, and Pool is melting fast. Shortly thereafter, Pool cuts his own hand off and crams it into Sabretooth's lungs, which sadly doesn't take. Deadpool is then ignobly shot down by the Director, Poochie, and a bunch of goons; the Director then mails Pool's hand and a taunting note to Wolverine. And somehow Weapon X got a series out of this.

Not loving this issue either: Pool's out for vengeance in the traditional (cliche) manner, but doesn't seem especially broken up about Vanessa's death. Like it was just the excuse he needed to go on the warpath. (Maybe Pool gets more emotional in a prior issue, maybe.) At any rate: I think I liked Tieri's run on Iron Man better...