Honestly, I'm not sure why they're yelling for his help, anyway.

The cover is a great one, and I think this series had a few in there; but it's the second of a three-parter, and the parts I recall were in the other two. It's also part of a crossover event I'm positive I've flipped through but am sure you could tell me anything was in it and I'd just have to trust you. From 2013, Thunderbolts #17, written by Charles Soule, art by Jefte Palo. Cover by Julian Totino Tedesco. 

The Thunderbolts at the time were a loose confederation, working under a system where they would take turns picking missions. When the Punisher gets to make a pick, he selects...some mobsters; which Deadpool calls the least surprising thing ever. But, Frank had picked the Paguro crime family, who were so behind the scenes he'd never been able to get at them. Unfortunately, the day of the mission coincides with Thanos's invasion of New York; but Frank isn't about to let a little thing like that hold them up. 

Red Leader was losing his intelligence, while Red Hulk is helping him not out of the kindness of his heart, but just to avoid losing a useful tool. Mercy had gone berserk, since the entire city maybe needed to be put out of its misery. Frank, Elektra, and Venom were murdering their way through the Paguros' goons; when they notice gas. While they don't know what it is, it's not hurting them, so they ignore it: Red Leader explains it's Terrigen Mist, and they also ignore it...even as it transforms some goons into Inhumans!

Meanwhile, having wandered off last issue, Deadpool is still looking for some pizza. Which he finally gets to, but the punchline has to wait until the next issue; and it's not bad.