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It's not ebola in this story, but eh, close enough: "Deadly Peril at 20,000" from House of Mystery #284, story by
Carl Wessler, art by Jess Jodloman. Mr. and Mrs Logan are returning to the United States after a second honeymoon in Africa; and it's pretty obvious from the start Mr. Logan is fading fast. A doctor examining him realizes Mr. Logan has deadly "pneumonic plague," but the plane is already near the halfway point and can't divert back.
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Mr. Logan dies, but when the doctor says his body will have to be disposed of to protect the other passengers, Mrs. Logan loses it and starts threatening people with a pair of scissors. (This comic's from 1980, I'm not sure anything had to be checked then.) The doctor and stewardess try to give Mrs. Logan a chance, but they have to blow a window and suck the Logans out of the plane. Harsh but fair. (I figure everyone on that plane would've been exposed by then, but the story writes it off as a happy ending.)
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(EDIT: "Stay your hand!" was the "Slow your roll!" of its day...)
Also this issue: early Keith Giffen art, in "The King and the Dragon!" (Story by Bud Simons, inks by John Celardo.) A mad king sends knight after knight to their deaths, in the hopes of stealing the dragon Goldclaw's treasure horde; but Goldclaw may have a plan to stop the senseless slaughter so he can get some sleep...
This was closer to the end than the beginning of House of Mystery's thirty-plus year run, but they still had some issues to go.
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